The Best Chicken Alfredo Lasagna: A Creamy Comfort Food Classic

There’s something undeniably satisfying about the combination of tender chicken, creamy sauce, and perfectly cooked pasta layered together in a casserole dish. Chicken Alfredo Lasagna brings together the best of two beloved Italian-American classics – the rich, velvety texture of Alfredo sauce and the comforting layers of lasagna – creating a dish that’s guaranteed to become a family favorite.

Unlike traditional lasagna recipes that rely on ricotta cheese and tomato sauce, this Chicken Alfredo Lasagna features a luxurious spinach Alfredo sauce that elevates the dish to new heights. What’s more, this recipe strikes the perfect balance between impressive flavor and straightforward preparation, making it ideal for both weeknight dinners and special occasions.

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Why You’ll Love This Recipe

Home cooks everywhere are falling in love with this Chicken Alfredo Lasagna recipe for several compelling reasons:

First, it’s remarkably easy to prepare, even for those who might feel intimidated by making lasagna from scratch. The straightforward process yields restaurant-quality results without requiring advanced culinary skills.

Second, the creamy spinach Alfredo sauce provides a delightful twist on classic lasagna flavors. The combination of freshly grated Parmesan cheese, tender spinach, and perfectly seasoned chicken creates layers of flavor that make each bite more delicious than the last.

Finally, this recipe is incredibly versatile. Whether you’re cooking for picky eaters, planning a dinner party, or looking for make-ahead meal options, Chicken Alfredo Lasagna delivers on all fronts.

Ingredients You’ll Need

For the Chicken

• 1 pound chicken tenders (or boneless chicken breast)
• 1 tablespoon olive oil
• 1/2 teaspoon black pepper
• 1 teaspoon salt
• 1/2 teaspoon cayenne or chili powder
• 1 teaspoon garlic powder
• 1 teaspoon Italian seasoning

For the Creamy Spinach Alfredo Sauce

• 4 tablespoons butter
• 1 medium onion, finely diced
• 4 cloves garlic, minced
• 1/2 teaspoon salt
• 1/4 teaspoon black pepper
• 1/4 teaspoon chili flakes
• 1 teaspoon Italian seasoning
• 3 tablespoons all-purpose flour
• 2 cups milk
• 1 cup heavy cream
• 1 cup freshly grated Parmesan cheese
• 2 cups chopped fresh spinach

For Assembly

• 14-15 lasagna sheets
• 3 cups shredded mozzarella cheese
• Fresh parsley, chopped (for garnish)

Step-by-Step Instructions

Preparing the Lasagna Noodles

1. Bring a large pot of salted water to a boil.
2. Cook the lasagna sheets according to package instructions until they reach al dente texture – tender but still firm to the bite.
3. Carefully remove each sheet and lay them flat on a clean kitchen towel, ensuring they don’t touch each other to prevent sticking.

Making the Chicken

1. In a bowl, combine the chicken tenders with olive oil, salt, pepper, cayenne (or chili powder), garlic powder, and Italian seasoning. Make sure the chicken is evenly coated with the seasoning mixture.
2. Heat a large skillet over medium-high heat.
3. Cook the seasoned chicken tenders for approximately 4-6 minutes per side until they’re golden brown on the outside and fully cooked inside.
4. Transfer the cooked chicken to a cutting board and let it rest for a few minutes.
5. Cut the chicken into small, bite-sized chunks and toss them back into the pan to coat with any remaining cooking juices for extra flavor.

Creating the Creamy Spinach Alfredo Sauce

1. In a large saucepan, melt the butter over medium heat.
2. Add the diced onion and sauté until soft and translucent, about 3-4 minutes.
3. Add the minced garlic and cook for another 30 seconds until fragrant.
4. Stir in the salt, pepper, chili flakes, and Italian seasoning.
5. Sprinkle the flour over the mixture and cook for about 1 minute, stirring constantly to prevent burning.
6. Gradually whisk in the milk and cream, ensuring there are no lumps.
7. Continue cooking, stirring frequently, until the sauce thickens enough to coat the back of a spoon.
8. Remove from heat and stir in the freshly grated Parmesan cheese until melted and fully incorporated.
9. Fold in the chopped spinach and stir until it begins to wilt. The residual heat will continue cooking the spinach as you assemble the lasagna.

Assembling the Lasagna

1. Preheat your oven to 375°F (conventional oven, bottom burner only).
2. Spread a thin layer of the Alfredo sauce on the bottom of a 9×13-inch baking dish.
3. Arrange a layer of lasagna sheets over the sauce, slightly overlapping if necessary.
4. Spread a generous layer of Alfredo sauce over the pasta sheets.
5. Sprinkle one-third of the chopped chicken evenly over the sauce.
6. Add a layer of shredded mozzarella cheese.
7. Repeat the layering process twice more: pasta, sauce, chicken, and cheese.
8. Top with a final layer of lasagna sheets, the remaining sauce, and a generous covering of mozzarella cheese.

Baking to Perfection

1. Insert 6-8 toothpicks or skewers into the lasagna (these will serve as « tent poles » to prevent the foil from sticking to the cheese).
2. Cover the dish with aluminum foil, tenting it slightly over the toothpicks.
3. Bake covered for 40 minutes.
4. Remove the foil and switch the oven to broil setting.
5. Broil for 2-3 minutes, watching carefully, until the cheese on top is melted, bubbly, and slightly charred in spots.
6. Remove from the oven and let the lasagna rest for about 15 minutes before serving.
7. Garnish with freshly chopped parsley.

Creative Variations

Chicken Alfredo Lasagna Rolls

For an elegant twist on the traditional layered approach, try making Chicken Alfredo Lasagna Rolls:

1. Cook the lasagna sheets until just pliable.
2. Mix the cooked, chopped chicken with some of the Alfredo sauce and spinach.
3. Spread this mixture evenly over individual lasagna sheets.
4. Roll each sheet up tightly.
5. Place the rolls seam-side down in a baking dish.
6. Pour the remaining Alfredo sauce over the rolls.
7. Top with mozzarella cheese and bake as directed in the main recipe.

Make-Ahead and Storage Tips

This Chicken Alfredo Lasagna is perfect for meal prepping and freezing:

• Refrigerator Storage: The assembled and baked lasagna will keep in the refrigerator for up to one week. Cover tightly with foil or transfer portions to airtight containers.
• Freezing Unbaked: Assemble the lasagna completely, cover tightly with plastic wrap and foil, and freeze for up to three months. Thaw in the refrigerator overnight before baking.
• Freezing Baked: Let the baked lasagna cool completely, then portion and freeze in airtight containers for up to three months. Reheat individual portions in the microwave or oven.

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• The Ultimate Chicken Philly Cheesesteak
• Spicy Firecracker Beef

What sets this Chicken Alfredo Lasagna apart is its perfect balance of convenience and flavor. The creamy spinach Alfredo sauce provides richness without overwhelming the delicate chicken flavor, while the layers of pasta add satisfying texture to every bite.

Whether you’re looking to impress dinner guests or simply want to treat your family to something special, this Chicken Alfredo Lasagna delivers unforgettable flavor with surprising ease. Give it a try, and it might just become your new go-to comfort food classic!